Vornia Biomaterials designs, develops and fabricates customised biomaterial solutions for medical device manufacturers and providers who need to add differentiation to their products in the marketplace.

Research

Vornia Lab 1

Vornia participates and leads many medium and long term research projects, this page provides a list of research projects funded under the FP7 funding scheme, and the EU Framework Program for Research and Innovation; Horizon 2020.

Current Projects

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ptrick NUER

On June 30th 2016 Vornia’s Patrick Duffy attended the very successful UK Society for Biomaterials (UKSB) Conference event held in Westminster, London and presented a poster to disseminate some of the excellent research activities being pursued as part of the NEURIMP project .

LogoMOZART

The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. We expect that MOZART approaches will significantly reduce the healing time of nonunion bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.

Horizon 20200605-SFI-

MatrixAssay CMYK

Matrixassay aims to tackle many of the problems with current day cell migration assays. Matrixassay is a project based around the cell migration assays which are commonly used to study wound healing, cancer cell invasion, and tissue development. There are a number of primary problems associated with the gap closure assays that hamper the effectiveness and potential of cell migration assays. The main objective of this project is to develop a prototype novel cell migration assay, which will significantly improve the predictive power of cell-based assays while avoiding problems associated with existing assays, based on seeding cells precisely on pristine extracellular matrix tissue mimics with native-like cell-functionality and reproducible migration zones. This project will have important impacts on both industrial and academic research.

Horizon 20200605-SFI-

HyMedPoly aims to develop new therapies based on biomedical polymers and inorganic materials.  10 universities and companies from across Europe are creating a cohort of 15 European Industrial Doctorates to synthesize new biopolymers with added antibacterial functionality and develop functionalized bioactive ceramics and glasses that can act as active agents to kill bacteria and prevent their growth. The new material systems from HyMedPoly are aimed at applications such as wound care, implants and bio film prevention. HyMedPoly will offer a joint training programme at world class academic and industrial institutes, combining technical knowledge with hands-on training in state-of-the-art research projects related to key issues that determine the future therapies of antibacterial materials. Vornia will develop novel hydrogel based hybrid antibacterial polymers for wound healing applications and will use novel supercritical carbon dioxide based green technology in order to avoid large scale usage of solvents. The polymers produced will be suitably functionalized and thoroughly characterized with respect to chemical, thermal and antibacterial properties.

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Horizon 20200605-SFI-

ReBioStent logo

The main concept of the ReBioStent is the production of biodegradable and biocompatible resorbable stents using highly INNOVATIVE, NOVEL, SMART and MULTIFUNCTIONAL materials to overcome the shortcomings of the currently available stents. The project has a consortium of fourteen partner organisations from five countries including Germany, Italy, Ireland, Spain, and United Kingdom. The project started in January 2014 and will complete the production of the stent device within three years. The main focus for Vornia is the development of unique polymers with defined mechanical properties, biocompatibility and controlled degradation. The aim is to prevent common complications associated with conventional stents such as inflammation, in stent restenosis and thrombosis.

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Neurograft logo

Nerve autograft is the “gold standard” surgical intervention that demands autologous tissue extraction and results in function loss at the donor site.
The goal of the project is the validation of biomaterials structural plasticity and those compatible manufacturing technologies that will enable the generation of a tubular structure containing an intraluminal microstructure based on an array of aligned channels or fibers. The regenerative properties of this prototype will also be validated in an in vivo model. This project proposal will take advantage of partners’ experience in the design of medical devices composed of natural and synthetic biomaterials and in scaled-up production mechanization technologies for the generation of the most effective peripheral nerve implant. This Project has received funding from the European Community’s Seventh Framework Programme(FP7-NMP2013-SME-7) under grant agreement no 604450.

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Completed Projects

Neurograft logo

Development of functionalised cell seeded bioartificial organ for transplantation in nerve repair. Neurograft is a multinational research project focussed on functional spinal cord repair and regeneration. Functional artificial spinal cord conduits are the main goal of this European project. The ultimate incarnation of the project will be an artificial spinal cord conduit prepared by Vornia scientists combined with neural stem cells and a novel immune modulating antibody called interleukin-37. This project involves commercialisation of this exciting new technology. Vornia’s involvement is key to the success of the project, as Vornia collagen will be used as the conduit material and Vornia scientists will design and develop the conduit itself.

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0605-7th-Framework-Logo0605-SFI-

 
Tendon_Regeneration logo

Targeting functional tendon regeneration using a loaded biomimetic scaffold. An integrated pan-European approach. Tendon Regeneration is a Marie Curie Industry-Academia Partnerships and Pathways project. It proposes to develop a tendon repair product based on collagen-resilin fibres. Resilin is a super elastic natural polymer which may provide elasticity to the fibres that mimics the properties of healthy tendon. Vornia scientists have developed and produced the collagen-resilin fibres and are now quantifying and optimising the mechanical and biological properties of the fibres for tendon repair. These scientists have come to Vornia as Marie Curie Fellows seconded from academic partner institutions, bringing a broad range of expertise into the Vornia laboratory.

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SevenPeople
MarieCurie

 
Green nano mesh logo

Targeting hernia operation using sustainable resources and green nanotechnologies. An integrated pan-European approach. Green Nano Mesh is a FP7 project funded under the thematic area of ‘Substitution of materials or components utilising green nanotechnology.’ Hernia operations are among the most common surgical procedures (20 million operations/year worldwide). Currently available hernia repair products are made from plastics which are often associated with negative inflammatory reactions, implant failure and/or hernia reoccurrence. Furthermore, the production of these polymers is not environmentally conscious. The aim of the project is to develop prototypes for hernia repair using natural biopolymers and eco-friendly green nanoprocesses that can be translated to clinical use as quickly as possible. The role of Vornia in the GreenNanoMesh project is to supply a range of natural and ecologically sustainable biopolymers and electrospun meshes suitable for soft tissue repair.

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